The free energy of microemulsion formation can be considered to depend on the. Preparation and evaluation of microemulsion containing antihypertensive drug article pdf available in international journal of applied pharmaceutics 105. Preparation, optimization and characterization of microemulsions 169 to different oils, surfactants and cosurfactants and stirred on magnetic stirrer for 24 hours. Particularly the preferred anionic surfactants include alkyl esters of inorganic or organic acids with or without polyalkoxylated group included. From the xrd we know that all samples are single phase. The research interest is preparation and characterization of oilinwater and waterinoil emulsions. In other studies docetaxel ow microemulsion is reported to have a relative bioavailability of 519.
Recent advances in nanoparticle preparation by spray and. Microemulsions mes are clear, thermodynamically stable systems. Microemulsion formed with several association structures emulsion, micelles, various gels and oily dispersions depending on. Pdf preparation and evaluation of microemulsion formulations of. Microemulsions are prepared by the phase titration method and can. Cefaclor monohydrate loaded microemulsion formulation for topical application. Among them, a precipitation in microemulsio n has been shown as a perspective method for the preparation of magnetic nanopartqicles of controlled size and morphology ko ak et. Construction of phase diagram is a useful approach to study the complex series of interactions that can occur when different components. They were used to solubilize drugs and to improve topical drug availability. Pdf naproxen np is an example of a nonsteroidal antiinflammatory drug. Experimental design 32 was applied in the formulation of microemulsion by varying concentrations levels of oil and smix and measuring globule size gs and drug loading dl as the responses. Nowadays, scientists have been putting more efforts in investigating more applications of microemulsion.
In addition, due to a strong kinetic stability, nanoemulsions are less sensitive to physical and chemical changes. Micro emulsion are having wide applications in colloidal drug delivery systems for the purpose of drug targeting and controlled release. Microemulsion method offers the advantages of ultralow interfacial tension, large interfacial area, and being thermodynamically stable and affords monodispersed nanoparticles. Oil and water are immiscible and they separate into two phases when mixed, each saturated with traces of the other component capek, 1999.
Generally, a microemulsion consists of oil, water, surfactant, and sometimes cosurfactant. The objective of this study was to formulate optimal formulations of microemulsions mes and evaluate their feasibility for delivery of resveratrol into human skin ex vivo. The invention relates to a reagent and particularly relates to a method for preparing a stable micro emulsion kit. A reverse microemulsion differs from an emulsion in that the tail groups of the surfactants orientate outwards microemulsions. A microemulsion can be defined as a thermodyna mically stable isotropic dispersion of two. The major drawbacks of this method include harsh processing conditions e. Generally the aqueous mixture consists of salt or other substances and the oil part contains hydrocarbons or olefins. In this paper, we are going to discuss two main topics. Methods of preparation of novel emulsion slideshare. Development of a simple method to improve the solubility and oral absorption of. Design and formulation of optimized microemulsions for dermal.
Sep 09, 2009 preparation of the microemulsion base and microemulsion systems containing different concentrations of salicylic acid. Pg as surfactantcosurfactant mixture scos in ratio of 15. Steps for synthesis of sns nanoparticles in conventional sbme method, there are two schemes for formation of nanoparticles from microemulsion. Disadvantages associated with microemulsion method are these. However, the catalyst preparation based on microemulsion method has been scarcely studied. Thus, i would like to talk about what is emulsion, what are the main characteristics of emulsions, what are the existing methods for preparations of emulsions and how to make simple emulsions.
The microemulsion system is turning to be more viscous with addition of water and thus may help in the slow diffusing of drug at infinite dilution. Microemulsion method is one of the recent and ideal techniques for the preparation of inorganic nanoparticles yu, et al. To make the suspension suitable for administration, it is made free of the internal phase and surfactants by means of diultrafiltration in order. Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation of microemulsions formation of microemulsion factors affecting. Phase titration method microemulsions are prepared by the spontaneous emulsification method phase titration method and can be depicted with the help of phase diagrams. May 15, 2014 if desired, combinations of various surfactants can be used for the preparation of an aqueous, stable, vocfree microemulsion based antimicrobial disinfectant andor cleaning composition. The objective of this work was to prepare and evaluate sa me systems. Mandal baroda college of pharmacy, vadodara, india. Anna zielinskajurek, joanna reszczynska, ewelina grabowska and adriana zaleska march 16th 2012. Pdf preparation and evaluation of microemulsion containing. Several authors have reported preparation of microemulsions. Pdf nanoparticles preparation using microemulsion systems. These results indicate that the microemulsion formulation may be appropriate.
Preparation and characterization of oilinwater and waterin. The synthesis parameters such as stirring rates, ratios of oilcosurfactant, oil phases. The aim of the present study was to design novel ow microemulsion of glimepiride and to study its. Microemulsion polymerization is a complex heterogeneous process where transport of monomers, free radicals and other species such as chain transfer agent, cosurfactant and inhibitors between the aqueous and organic phases, takes place. The compositions of primary waterinoil wo microemulsion were obtained using pseudoternary phase diagrams, and then wow microemulsion was prepared adopting the twostep heterotherm method. Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. Methods of formulation of microemulsion phase titration method water titration method microemulsion are prepared by spontaneous emulsification method phase titration method and can be depicted using phase diagrams. This result indicated that free drug absorption might not be a major mechanism for the enhanced intestinal absorption. In this study, nano and microemulsions were also produced by a method called titration method involving a twostep process. Pharm quality assurance department of pharmaceutics faculty of pharmacy jamia hamdard new delhi 110062 supervisor dr. The microemulsion method is one of the ideal techniques for the preparation of inorganic nanoparticles, yet the mechanism of nanoparticle formation in the microemulsion has not yet been understood well.
In the study, conventional liposomes and deformable transfersomes were obtained and compared to two different types of microemulsions as potential dermal delivery carriers for meloxicam, a nonsteroidal antiinflammatory drug. Controllable particles sizes of starch nanoparticles were synthesized via a precipitation in waterinoil microemulsion approach. Salicylic acid sa is a keratolytic agent used in topical products with antimicrobial actions. Surfactantfree microemulsion composed of oleic acid, n. In fact protein is biopolymer, which is commonly used for preparation of nano structured molecules for drug delivery.
Size controlled synthesis of starch nanoparticles by a. Among various preparation of nanoparticles methods, the use of microemulsion is an effective route for yielding a wide range of mo nodisperse nanoparticles of different size and shape. Preparation of nano and microemulsions using phase inversion. Full text development of a novel microemulsion for oral absorption. Formulation and evaluation of microemulsion based topical. Formulation and characterization of microemulsion system. Some of its applications are well known and are extensively used, such as, catalysis, submicron particles preparation by microemulsion polymerization, conversion of solar energy and liquidliquid extraction. The conductivity of wow microemulsion was measured to lie between 250. Prospective and challenges of microemulsion as a novel. Microemulsion research articles omics international. The kit comprises a reagent r1 and a reagent r2, wherein the reagent r1 comprises a taps buffered solution, colipase, sodium deoxycholate, sodium chloride, calcium chloride, taurodeoxycholic acid and sodium azide. Pseudoternary phase diagram was used to define the microemulsion area, and samples from the best combinations, i. Preparation, characterization and relative bioavailability of.
The formulation is prepared above the melting point of the lipid to form the microemulsion. Preparation of thiolfunctionalized gold nanoparticles by the microemulsion method a ternary phase diagram of the toluenetoabwater system at 25 c is shown in fig. Nine batches of microemulsions of each system were prepared by titration method according to experimental design. Nanoemulsions and microemulsions have a larger surface area per unit volume than do macroemulsions because of their size. Feb 03, 2017 methods of formulation of microemulsion phase titration method water titration method microemulsion are prepared by spontaneous emulsification method phase titration method and can be depicted using phase diagrams. Herein, we report a surfactant free microemulsion denoted as sfme, consisting of oleic acid oil phase, water, and npropanol without the amphiphilic molecular structure of a traditional surfactant.
Cn1026218a preparation method of microemulsion kit. Microemulsion research articles these are a thermodynamically stable, isotropic liquid mixture of oil, water and surfactant. The samples were centrifuged at 8000 rpm for 10 minutes and the drug content in the supernatant was analysed after proper dilution with methanol as described in. The free energy of microemulsion formation can be considered to. However, the method known as precipitation in reverse microemulsion allows the preparation of magnetic nanoparticles with mean diameters smaller than 10 nm. A platform for improving dissolution rate of poorly water soluble drug surjyanarayan mandal and snigdha. Characterization with new developed uplc method and stability. Hydrogel thickened microemulsions were characterized for ph, viscosity, spreadability. The droplets size in the microemulsion as measured using optical microscope was less than 1 m. The microemulsion system thus, shows a structural change from oil continuous system to water continuous, which has higher viscosities than the former 34.
Nanoparticles preparation using microemulsion systems. Polymer chitosan coated magnetic nanoparticles with mean diameters smaller than 10 nm cannot be prepared by coprecipitation as this method is useful for obtaining larger nanoparticles. The performed studies allowed for optimization of the preparation method and composition of the investigated systems. Aug 01, 2016 compared with the cosurfactant free microemulsion system, ethanol or glycerol was used as a cosurfactant to replace a certain proportion of surfactant tween 80 and the microemulsion systems were constructed based on the same preparation method. In such cases, microemulsion is spontaneous and the resulting dispersion is thermodynamically stable 16,17. Oilinwater mes were formulated using surfactant s peg8 capryliccapric glycerides and cosurfactant cos polyglyceryl6isostearate. Nanoparticles preparation using microemulsion systems, microemulsions an introduction to properties and applications, reza najjar, intechopen, doi. Topical antiacne microemulsion formulation of essential oil.
In this articles various techniques have been discussed in detail for the preparation of nanoparticles using natural polymers chitosan,alginate and proteins such as albumin,gelatin,legumin. Characterization of microemulsions prepared using isopropyl. Cn102764240a alprostadil lyophilized microemulsion, and. The prepared microemulsion was evaluated for its particle size, shape, zeta. An me gel base composed of 35% ipm, 20% water, and 45% tween 80. The phase behavior of the ternary system was investigated, showing that there were a singlephase. This method is suitable for hydrophobic drug and showed high percentage of drug entrapment. The microemulsion method allows the production of a very narrow size distribution of metal particles, with an average size smaller than that prepared by conventional methods and their sizes can be varied with the preparation conditions 2. Preparation and evaluation of microemulsion systems. A micro emulsion system consists of aqueous domains, called reverse micelles, dispersed in a continuous oil phase.
1473 730 1453 316 1060 1074 25 302 625 1594 1391 599 199 631 633 71 491 1455 594 511 1223 1611 533 1570 1548 472 116 1381 1564 490 1120 88 408 1212 125 1134 80 196 1121 998 1327 70 1334 463 144 249